Related Experiment Video For biomarker
Updated: Jun 17, 2025

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
Published on: November 11, 2014
HSP47 in human diseases: Navigating pathophysiology, diagnosis and therapy
Essak S Khan1,2,3, Tobias Däinghaus1,2
1Posttranscriptional Gene Regulation, Cancer Research and Experimental Hemostasis, University Medical Center Mainz (UMCM), Mainz, Germany.
Abstract:
Heat shock protein 47 (HSP47) is a chaperone protein responsible for regulating collagen maturation and transport, directly impacting collagen synthesis levels. Aberrant HSP47 expression or malfunction has been associated with collagen-related disorders, most notably fibrosis. Recent reports have uncovered new functions of HSP47 in various cellular processes. Hsp47 dysregulation in these alternative roles has been linked to various diseases, such as cancer, autoimmune and neurodegenerative disorders, thereby highlighting its potential as both a diagnostic biomarker and a therapeutic target. In this review, we discuss the pathophysiological roles of HSP47 in human diseases, its potential as a diagnostic tool, clinical screening techniques and its role as a target for therapeutic interventions.
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