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Psilocybin for clinical indications: A scoping review
Kim Madden1,2,3,4, Breanne Flood1,3, Darren Young Shing5
1Research Institute of St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Journal of Psychopharmacology (Oxford, England)
|August 13, 2024
Summary
This review of psilocybin research found most studies focus on psychiatric disorders and have small sample sizes. More high-quality trials are needed, potentially exploring new indications like chronic pain.
Area of Science:
- Psychopharmacology
- Medical Research
- Systematic Reviews
Background:
- Psychedelic drug research has seen a resurgence since the early 1950s.
- Interest in psilocybin for medical applications is growing.
Purpose of the Study:
- To comprehensively review existing literature on psilocybin for medical uses.
- To identify research gaps and areas for future study in psilocybin therapeutics.
Main Methods:
- Conducted a systematic scoping review of clinical indications for psilocybin.
- Searched Medline and Embase databases for relevant studies.
- Analyzed data descriptively, extracting information on study design, participants, and outcomes.
Main Results:
- Included 193 published and 80 ongoing studies on psilocybin.
- Depression was the most common indication studied (28%), followed by substance use (14%).
- Only 12% of studies were randomized controlled trials, with a median of 22 participants.
Conclusions:
- Most psilocybin studies have small sample sizes and focus on psychiatric conditions.
- There is a need for high-quality randomized trials.
- Further research should explore other potential indications, such as chronic pain.
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