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Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Predictive accuracy of the ASIG algorithm in a prospective systemic sclerosis cohort undergoing annual screening for
Zoe Brown1,2, Kathleen Morrisroe1,2, Dylan Hansen2
1Department of Medicine, The University of Melbourne at St Vincent's Hospital, Melbourne, Victoria, Australia.
Abstract:
The Australian Scleroderma Interest Group (ASIG) algorithm for screening pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) requires only respiratory function tests and serum N-terminal pro-brain natriuretic peptide as first-tier tests, and is recommended in international guidelines. In this communication, we present the findings of the application of the ASIG screening algorithm to a Singaporean cohort undergoing prospective annual screening for PAH, which shows a high negative predictive value. The ASIG algorithm may offer an alternative to more complex and costly SSc-PAH screening algorithms.
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