Related Experiment Video
Updated: Jun 17, 2025

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
Risk factors of malnutrition in children with congenital heart disease: a meta-analysis
Chen Zhang1, Banghong Xu1, Cuiying Zhu1
1Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
Insights
Malnutrition in children with congenital heart disease (CHD) is linked to pulmonary hypertension, low birth weight, and pneumonia. Understanding these factors is crucial for improving nutritional support and care for affected children.
Area of Science:
- Pediatrics
- Cardiology
- Nutrition Science
Background:
- Malnutrition is a significant concern in children with congenital heart disease (CHD).
- Identifying associated factors is essential for effective treatment and care strategies.
- Evidence-based approaches are needed to address nutritional deficits in this vulnerable population.
Purpose of the Study:
- To evaluate the associated factors of malnutrition in children with congenital heart disease (CHD).
- To provide evidence for optimizing the treatment and care of children suffering from malnutrition and CHD.
Main Methods:
- A systematic literature search was conducted on the PubMed database up to June 25, 2023.
- Included studies focused on the associated factors of malnutrition in children with CHD.
- A meta-analysis was performed using RevMan 5.3 software to synthesize the findings.
Main Results:
- Thirteen studies involving 8,031 children with CHD were analyzed.
- Factors associated with growth retardation included pulmonary hypertension (OR=3.81), low birth weight (OR=2.69), and parents' height (OR=2.15).
- Factors associated with low body weight were pulmonary hypertension (OR=3.77), low birth weight (OR=3.04), and pneumonia (OR=2.35).
Conclusions:
- Pulmonary hypertension, low birth weight, and pneumonia are key risk factors for malnutrition in children with CHD.
- Healthcare providers must fully understand these risk factors to guide nutritional support and nursing care.
- Strengthening nutritional interventions and enhancing care are vital for reducing malnutrition in children with CHD.
Background:
The associated factors of malnutrition in children with congenital heart disease (CHD) must be evaluated to provide evidence for the treatment and care of such children.
Methods:
Two investigators searched the PubMed database until 25 June 2023 for literature about the associated factors of malnutrition in children with CHD. A meta-analysis of associated factors of malnutrition was performed by RevMan 5.3 software.
Results:
Thirteen studies involving 8,031 children with CHD were included. Pulmonary hypertension (OR = 3.81, 95% CI: 2.46-4.12), low birth weight (OR = 2.69, 95% CI: 1.25-5.77) and parents' height (OR = 2.15, 95% CI: 1.89-2.92) were the associated factors of growth retardation (all P < 0.05). Pulmonary hypertension (OR = 3.77, 95% CI: 3.13-4.24), low birth weight (OR = 3.04, 95% CI: 2.61-4.18) and pneumonia (OR = 2.35, 95% CI: 2.08-2.83) were the associated factors of low body weight of children with CHD (all P < 0.05).
Conclusions:
Medical staff should fully understand the risk factors, strengthen nutritional support and enhance nursing care for children with CHD to reduce malnutrition.
Related Concept Videos
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
Pathophysiology of Heart Failure
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Pathophysiology of Cardiac Performance
Factors Influencing Heart Rate
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...

