Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Cholinergic hypothesis of depression].

M Leboyer, O Plaisant

|November 1, 1985

Summary

This summary is machine-generated.

Acetylcholine plays a role in depression, with evidence suggesting cholinergic dysfunction contributes to symptoms like sleep disturbances. This research could improve antidepressant selection and depression risk assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association Between Metabolic Syndrome, Obesity, and Cognitive Performances in Individuals With Bipolar Disorders: Cross-Sectional and Longitudinal Analyses in the FACE-BD Cohort.

Acta psychiatrica Scandinavica·2025

Same author

Substance use disorders in outpatients with bipolar disorder and pain complaints.

Journal of affective disorders·2025

Same author

Relationships between cognition, functioning, and quality of life of euthymic patients with bipolar disorder: Structural equation modeling with the FACE-BD cohort.

European psychiatry : the journal of the Association of European Psychiatrists·2024

Same author

Cognition and gut microbiota in schizophrenia spectrum and mood disorders: A systematic review.

Neuroscience and biobehavioral reviews·2024

Same author

Functioning and neurocognition in very early and early-life onset bipolar disorders: the moderating role of bipolar disorder type.

European child & adolescent psychiatry·2024

Same author

Risk factors of suicide re-attempt: A two-year prospective study.

Journal of affective disorders·2024

Area of Science:

Neuroscience
Psychiatry
Biochemistry

Context:

The cholinergic system's role in affective disorders remains incompletely understood.
Current biochemical methods for studying the cholinergic system are limited.
Indirect evidence supports the cholinergic hypothesis of depression.

Purpose:

To explore the potential involvement of acetylcholine in depressive disorders.
To review indirect evidence supporting the cholinergic hypothesis of affective disorders.
To discuss the implications for antidepressant drug development and risk assessment.

Summary:

Cholinergic agonists can induce depressive symptomatology.
Central cholinergic dysfunction may explain sleep and neuroendocrine abnormalities in affective disorders.

Related Experiment Videos

Existing research provides indirect support for acetylcholine's role in depression.

Impact:

Findings could guide the selection of more effective antidepressant medications.
New diagnostic tests for identifying individuals at high risk for depression may be developed.
This research highlights the importance of the cholinergic system in mental health.
Further investigation into the cholinergic system's role in depression is warranted.