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Updated: Oct 13, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
Abstract:
Is acetylcholine implicated in depressive disorders? Biochemical methods studying the cholinergic system are not well set up. Only indirect elements could confirm the cholinergic hypothesis of affective disorders. Cholinergic agonists induce depressive symptomatology. Moreover, a central, cholinergic dysfunction could be an explanation of sleep disturbances and of neuroendocrine abnormalities seen in affective disorders. These observations could be applied in two ways: a more precise choice of antidepressive drugs, and the use of new tests developed to detect population with high depression risk.
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