Bipolar disorder and oxidative stress: A bibliometric perspective

Area of Science:

• Neuroscience
• Psychiatry
• Biochemistry

Background:

• Oxidative stress and disrupted antioxidant defenses are implicated in bipolar disorder (BD) neurobiology.
• Increased oxidative stress correlates with apoptosis and neuronal damage in BD patients.

Purpose of the Study:

• To conduct a bibliometric analysis of research on bipolar disorder (BD) and oxidative stress.
• To identify key trends, influential publications, and emerging research areas in this field.

Main Methods:

• Bibliometric analysis of 2081 publications from 1986-2024.
• Data retrieved from Web of Science Core Collection.
• Analysis performed using R, VOSviewer, and CiteSpace software.

Main Results:

• The United States is the most productive country, and the University of Toronto is the leading institution.
• Bipolar Disorders is the most prolific journal.
• Keywords include "schizophrenia," "prefrontal cortex," and "nitric oxide," alongside "oxidative stress" and "bipolar disorder."

Conclusions:

• Research on BD and oxidative stress is expanding, underscoring its significance.
• Current hot topics include animal models, molecular mechanisms, inflammation, biomarkers, neurodegeneration, and metabolism.
• Future research priorities may focus on biological mechanisms, particularly biomarkers and inflammation in BD.