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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

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Published on: October 22, 2020

The relationship between smoking and rosacea: A Mendelian randomization study.

YuJia Cai^1,2, HaiFeng Zeng^1,2, MaoCan Tao^1,2

¹Department of Cosmetic Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Journal of Cosmetic Dermatology

|August 13, 2024

Summary

Previous smoking significantly increases rosacea risk, but current smoking does not. This study used Mendelian randomization to establish a causal link between past smoking habits and developing rosacea.

Keywords:

Mendelian rosacea smoking

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Area of Science:

Dermatology
Genetics
Epidemiology

Background:

Rosacea is a common condition with complex, multifactorial causes.
Previous studies suggest an association between smoking and rosacea, but causality remains unclear due to potential biases.

Purpose of the Study:

To investigate the potential causal relationship between smoking and rosacea risk using a robust genetic approach.
To differentiate the effects of previous versus current smoking on rosacea development.

Main Methods:

Mendelian randomization (MR) analysis was employed to assess causality.
Genetic data on smoking and rosacea were sourced from the FinnGen project and Neale Lab Consortium.
Multiple statistical methods (IVW, MR Egger, weighted median) and sensitivity analyses were utilized to ensure result validity.

Main Results:

Previous smoking was found to significantly increase the risk of rosacea (OR = 6.77, p = 0.0104).
No statistically significant association was observed between current smoking and rosacea risk (OR = 0.62, p = 0.6847).
Sensitivity analyses confirmed the robustness of the findings regarding previous smoking and rosacea.

Conclusions:

This Mendelian randomization study provides evidence supporting a causal link between previous smoking and an increased risk of rosacea.
While current smoking did not show an increased risk, the public should be advised to avoid smoking to prevent various smoking-related diseases.