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Pilot study evaluating treatment with sumatriptan for moderate to severe post-traumatic headache: A phase 2
Tara L Sharma1, Sylvia Lucas1,2, Jason Barber3
1Department of Neurology, University of Washington, Seattle, Washington, USA.
Headache
|August 13, 2024
Summary
This study found that keeping a daily headache diary is feasible for post-traumatic headache (PTH) patients. Sumatriptan may effectively treat PTH across different phenotypes, warranting further investigation.
Area of Science:
- Neurology
- Clinical Pharmacology
Background:
- Post-traumatic headache (PTH) is a common and persistent condition following traumatic brain injury.
- Limited research exists on pharmacological treatments for PTH.
Purpose of the Study:
- To assess the feasibility of patients with PTH maintaining a daily headache diary.
- To evaluate the efficacy of sumatriptan in treating PTH.
- To determine if PTH treatment outcomes vary by headache phenotype.
Main Methods:
- A single-arm, prospective, non-randomized phase 2 clinical trial.
- 40 participants with PTH were enrolled after screening 299 individuals.
- Participants used a headache diary and sumatriptan, reporting medication use and response.
Main Results:
- 15 participants met criteria for sumatriptan use and completed assessments.
- Average diary compliance was 80% in the final study month.
- Sumatriptan resolved 72% of treated headaches within 2 hours, irrespective of PTH phenotype.
Conclusions:
- Daily headache diaries are a feasible tool for tracking PTH symptoms.
- Sumatriptan shows preliminary efficacy in treating PTH across various phenotypes.
- Larger phase 3 trials are recommended to confirm sumatriptan's effectiveness for PTH.
