Related Experiment Video
Updated: Jul 7, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
The predictors of coronary slow flow in patients undergoing coronary angiography
Romi Ermawan1, Yusra Pintaningrum2, Yanna Indrayana2
1Faculty of Medicine, Mataram University, FK UNRAM, Jl. Pendidikan, No. 37, Mataram, NTB, Indonesia. romi@unram.ac.id.
Insights
Coronary slow flow (CSF) is a condition causing ischemic symptoms without artery blockage. Larger coronary artery diameter is a strong predictor of CSF in patients undergoing angiography.
Area of Science:
- Cardiology
- Vascular Medicine
- Diagnostic Imaging
Background:
- Coronary artery disease (CAD) presents challenges in specific populations with ischemic symptoms but no epicardial artery obstruction.
- This condition is characterized by slow coronary contrast flow, termed coronary slow flow (CSF).
Purpose of the Study:
- To identify predictors of coronary slow flow (CSF) in patients with ischemic symptoms.
- To investigate the relationship between coronary artery diameter and CSF.
Main Methods:
- A case-control study involving 60 subjects (30 with CSF, 30 with normal epicardial coronary artery angiogram - NECA).
- CSF was defined by a TIMI frame count (TFC) greater than 27 frames.
- Coronary artery diameter and random blood sugar were assessed as potential predictors.
Main Results:
- Coronary artery diameter and random blood sugar were significant predictors of CSF.
- In multivariate analysis, coronary artery diameter remained a significant predictor (adjusted OR 10.08, p < 0.001).
- An optimal cut-off for coronary artery diameter was >3.56 mm, with 76.7% sensitivity and 70.7% specificity (AUC = 0.787).
Conclusions:
- Coronary artery diameter is a strong predictor of coronary slow flow (CSF) in patients undergoing coronary angiography.
- These findings aid in understanding and potentially diagnosing CSF.
Background:
A new challenge in coronary artery disease treatment has emerged, where specific populations exhibit ischemic symptoms without any obstruction in the epicardial coronary artery. Instead, they exhibit slow coronary contrast flow, referred to as coronary slow flow (CSF). This study aims to identify several predictors of CSF.
Results:
This case-control study was conducted at the Regional General Hospital of West Nusa Tenggara Province in Indonesia from December 2016 to February 2024. The study involved sixty subjects, with 30 in each group of CSF and normal epicardial coronary artery angiogram (NECA). CSF is enforced by the TIMI frame count (TFC) greater than 27 frames. Among all the predictors studied, coronary artery diameter (p < 0.001) and random blood sugar (p = 0.049) were found to affect the CSF significantly. In the multivariate analysis, coronary artery diameter remained a significant predictor (adjusted OR 10.08, 95% CI 2.64-38.50, p < 0.001), with an optimal cut-off point of more than 3.56 mm, a sensitivity of 76.7%, and a specificity of 70.7% (AUC = 0.787, p < 0.001).
Conclusion:
The coronary artery diameter strongly predicts CSF in patients undergoing coronary angiography.
More Related Videos
Related Concept Videos
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Coronary Artery Disease I: Introduction
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome III: Diagnostic Studies

