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Whole-Eye Transplantation: How Far Are We From a Breakthrough?

Ingrid Bekono-Nessah¹, Kwaku A Duah-Asante², Daryl Poku³

¹Moorfields Eye Centre, St George's University Hospital, London, United Kingdom.

Ophthalmic Plastic and Reconstructive Surgery

|August 13, 2024

Summary

Whole-eye transplantation (WET) shows promise for patients with severe facial trauma, despite challenges. Advancements in surgical techniques and stem cell therapy offer hope for restoring quality of life.

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Area of Science:

Ophthalmology
Reconstructive Surgery
Transplantation Medicine

Background:

Traumatic facial injuries often lead to eye enucleation, significantly impacting patients' lives.
Whole-eye transplantation (WET) has historically been a challenging but sought-after reconstructive procedure.

Purpose of the Study:

To review the current literature on whole-eye transplantation (WET).
To assess the existing challenges and ethical considerations for WET programs.

Main Methods:

A narrative review methodology was employed.
Literature search using pertinent keywords across scientific databases.
Focus on articles related to ocular restoration and reconstructive surgery.

Main Results:

Surgical innovations, including vascularized composite allotransplantation, enable consideration of WET in facial transplant planning.
CD34-positive stem cells show potential as neuroprotective agents in WET.
Successful WET requires careful consideration of vascular and neural structures, alongside advancements in microsurgical techniques.

Conclusions:

Whole-eye transplantation (WET) holds significant potential for improving quality of life in patients with severe facial trauma.
Further research is necessary to establish the long-term viability and efficacy of WET.