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Updated: Jun 17, 2025

Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans
Published on: September 18, 2020
EVs move messes, not messages, at the synapse
Marina N Bostelman1, Heather T Broihier1
1Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Abstract:
Extracellular vesicles are known for intercellular signaling roles but can also serve to simply dispose of unwanted cargoes. In this issue, Bostelman and Broihier discuss new work from Rodal and colleagues (https://doi.org/10.1083/jcb.202405025) that refutes prior work by showing that extracellular vesicles at Drosophila neuromuscular junctions are not required for signaling and instead likely serve a proteostasis role.
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