Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary dapsone resistance in leprosy.

C Vaishnavi, N K Ganguly, B Kumar

    Indian Journal of Leprosy
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prize Winning Abstracts from BASEM Congress 2016.

    British journal of sports medicine·2017
    Same author

    Nocardia Mycetoma At Unusual Site.

    Indian journal of dermatology, venereology and leprology·2017
    Same author

    Tinea Cruris in Chandigarh.

    Indian journal of dermatology, venereology and leprology·2017
    Same author

    Penicillin Resistant Gonococci.

    Indian journal of dermatology, venereology and leprology·2017
    Same author

    Erythema Elevatum Diutinum with a Prolonged Bullous Phase.

    Indian journal of dermatology, venereology and leprology·2017
    Same author

    Reiter's Disease- Clinical Profile of Six Cases.

    Indian journal of dermatology, venereology and leprology·2017

    Primary dapsone resistance in leprosy was investigated using mouse models. Some M. leprae strains showed resistance to lower dapsone doses but were inhibited by higher concentrations.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Leprosy remains a significant global health challenge.
    • Dapsone is a primary treatment, but resistance is a growing concern.
    • Understanding primary dapsone resistance is crucial for effective treatment strategies.

    Purpose of the Study:

    • To investigate primary dapsone resistance in Mycobacterium leprae (M. leprae).
    • To evaluate the efficacy of different dapsone concentrations against M. leprae in vivo.

    Main Methods:

    • Foot pad inoculation of M. leprae into mice.
    • Administration of varying dapsone concentrations (0.001 g% and 0.01 g%) in mouse diets.
    • Monitoring M. leprae growth inhibition over a 9-month period.

    Related Experiment Videos

    Main Results:

    • Two out of 20 patients' M. leprae isolates showed partial inhibition at 0.001 g% dapsone.
    • Complete inhibition of M. leprae growth was observed at 0.01 g% dapsone concentration.
    • This suggests a dose-dependent effect of dapsone on M. leprae.

    Conclusions:

    • Primary dapsone resistance in M. leprae can occur.
    • Higher dapsone concentrations may overcome initial resistance.
    • Further research is needed to guide optimal leprosy treatment regimens.