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Generating kidney organoids based on developmental nephrology.

Yutaro Ibi1, Ryuichi Nishinakamura1

  • 1Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

European Journal of Cell Biology
|August 13, 2024
PubMed
Summary
This summary is machine-generated.

Kidney organoids derived from pluripotent stem cells (PSCs) show promise for transplantation. Researchers are assembling multiple renal progenitor cells to create complex, organotypic kidney structures for therapeutic applications.

Keywords:
Clinical transplantation therapyDevelopmental nephrologyHigher-order structureKidney organoid

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Area of Science:

  • Developmental biology
  • Regenerative medicine
  • Nephrology

Background:

  • Established protocols for inducing nephron and ureteric bud organoids from pluripotent stem cells (PSCs) leverage developmental nephrology insights.
  • Kidney organoids are currently utilized for disease modeling and drug screening.
  • Significant potential exists for kidney organoids in clinical transplantation therapy.

Purpose of the Study:

  • To review the developmental nephrology principles underlying renal progenitor induction.
  • To discuss recent advancements in kidney organoid technology for transplantation.
  • To identify remaining challenges in translating kidney organoids into clinical therapies.

Main Methods:

  • Induction of renal progenitor cells (nephron, ureteric bud, stromal) from PSCs.
  • Assembly of induced progenitors to recapitulate organotypic kidney structures.
  • Review of developmental nephrology knowledge and recent literature.

Main Results:

  • Successful induction and assembly of three key renal progenitors from mouse PSCs into higher-order kidney organoids.
  • Demonstration of organotypic kidney structure assembly from multiple progenitor types.
  • Overview of progress and challenges in the field.

Conclusions:

  • Kidney organoid technology, particularly higher-order organoids assembled from multiple progenitors, holds significant promise for clinical transplantation.
  • Further research is needed to address remaining challenges for successful therapeutic application.