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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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Rare craniofacial clefts: Surgical management protocols.

Mansoor Khan1, Hidayatullah1, Waqas Hayat1

  • 1Burns & Plastic Surgery Center, Hayatabad Medical Complex, Peshawar, Pakistan.

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|August 13, 2024
PubMed
Summary
This summary is machine-generated.

This study presents a simplified surgical technique for rare craniofacial clefts, achieving good outcomes and high parent satisfaction. Our experience aids surgeons in managing these complex cases.

Keywords:
Cleft lipCraniofacial abnormalitiesCraniofacial surgeryFacial cleftsOrofacial cleft

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Area of Science:

  • Craniofacial surgery
  • Plastic surgery
  • Pediatric surgery

Background:

  • Standardizing surgical protocols for rare craniofacial clefts is challenging due to low incidence.
  • This study focuses on a specific surgical management technique for these rare conditions.

Purpose of the Study:

  • To present a surgical management technique for rare craniofacial clefts.
  • To evaluate the postoperative results and parent satisfaction with the technique.

Main Methods:

  • A retrospective study of patients with craniofacial clefts from 2013 to 2022.
  • Assessment of outcomes based on parental satisfaction and objective evaluations by independent observers.

Main Results:

  • 61 patients with 89 rare craniofacial clefts were analyzed (2.42/100 prevalence).
  • Craniofacial clefts 4 and 5 were most common; 37.7% had multiple clefts, and 39.34% had associated anomalies.
  • 71.6% of parents reported high satisfaction, and 70.27% of patients showed good objective results.

Conclusions:

  • Standardization of surgical procedures for rare craniofacial clefts remains challenging due to their complexity.
  • The presented simplified technique offers a viable approach for managing various Tessier clefts.
  • This experience provides didactic and technical guidance for surgeons managing rare craniofacial clefts.