Reduced activity of locus coeruleus neurons in hypertensive rats

The effect of blood pressure on the neuronal activity of the locus coeruleus (LC) was investigated by means of electrophysiological techniques in rats anaesthetized with chloral hydrate. The mean neuronal discharge rate of noradrenergic neurons of the LC was reduced by 19% in spontaneously hypertensive rats (SHR) and by 25% in deoxycorticosterone acetate (DOCA)-salt hypertensive rats compared with their corresponding controls. The cellular activity of 27 out of 40 neurons was reversibly suppressed by acute, peripherally induced blood pressure increases in normotensive rats. Five neurons were reversibly activated and eight neurons were not affected. Conversely, acute decreases in blood pressure stimulated the neuronal activity of the LC in 10 out of 16 neurons. These findings support the hypothesis of the LC having a role in both short and long term regulation of blood pressure.