Human papillomavirus-associated subsequent malignant neoplasms among childhood cancer survivors
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View abstract on PubMed
Summary
This summary is machine-generated.Childhood cancer survivors face a tenfold increased risk of developing human papillomavirus-associated subsequent malignant neoplasms (HPV-SMNs). Early HPV vaccination and surveillance are crucial for improving long-term outcomes in these individuals.
Area Of Science
- Oncology
- Epidemiology
- Public Health
Background
- Childhood cancer survivors have an increased risk of subsequent malignant neoplasms (SMNs).
- Human papillomavirus (HPV) is implicated in various SMNs, but population-based risk data for survivors are limited.
Purpose Of The Study
- To estimate the population-based risk of HPV-associated subsequent malignant neoplasms (HPV-SMNs) in childhood cancer survivors.
- To identify risk factors and survival outcomes for HPV-SMNs in this population.
Main Methods
- Utilized longitudinal data from the Surveillance, Epidemiology, and End Results (SEER) program (1975-2018).
- Established a cohort of childhood cancer survivors (≥5 years survival).
- Calculated standardized incidence ratios (SIR) and used competing risk regression models.
Main Results
- 42 HPV-SMNs identified in 35,397 childhood cancer survivors (median 25 years post-diagnosis).
- Survivors had a 10-fold increased risk of HPV-SMNs (SIR 10.1).
- Age at diagnosis and primary cancer type influenced HPV-SMN development; HPV-SMNs increased mortality risk (HR 2.63).
Conclusions
- Childhood cancer survivors exhibit a significantly higher risk of HPV-SMNs with poorer survival.
- Implementing HPV vaccination and enhanced surveillance protocols is recommended to improve long-term health outcomes.
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