Efficient model-informed co-segmentation of tumors on PET/CT driven by clustering and classification information

Automatic tumor segmentation via positron emission tomography (PET) and computed tomography (CT) images plays a critical role in the prevention, diagnosis, and treatment of this disease via radiation oncology. However, segmenting these tumors is challenging due to the heterogeneity of grayscale levels and fuzzy boundaries. To address these issues, in this paper, an efficient model-informed PET/CT tumor co-segmentation method that combines fuzzy C-means clustering and Bayesian classification information is proposed. To alleviate the grayscale heterogeneity of multi-modal images, in this method, a novel grayscale similar region term is designed based on the background region information of PET and the foreground region information of CT. An edge stop function is innovatively presented to enhance the localization of fuzzy edges by incorporating the fuzzy C-means clustering strategy. To improve the segmentation accuracy further, a unique data fidelity term is introduced based on PET images by combining the distribution characteristics of pixel points in PET images. Finally, experimental validation on datasets of head and neck tumor (HECKTOR) and non-small cell lung cancer (NSCLC) demonstrated impressive values for three key evaluation metrics, including DSC, RVD and HD5, achieved impressive values of 0.85, 5.32, and 0.17, respectively. These compelling results indicate that image segmentation methods based on mathematical models exhibit outstanding performance in handling grayscale heterogeneity and fuzzy boundaries in multi-modal images.