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[Anatomical Lung Resection Following Neoadjuvant Chemoimmunotherapy: Technical Aspects and Case Reports]
Martin Eichhorn1,2, Florian Eichhorn1,2, Raffaella Griffo1
1Chirurgische Abteilung, Thoraxklinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
Zentralblatt Fur Chirurgie
|August 13, 2024
Summary
Neoadjuvant chemo-immunotherapy improves treatment for non-small cell lung cancer (NSCLC). This review examines perioperative safety, surgical techniques, and challenges after this therapy for resectable NSCLC.
Area of Science:
- Oncology
- Thoracic Surgery
- Pulmonology
Background:
- Neoadjuvant chemo-immunotherapy has become a standard treatment for resectable stage II-III non-small cell lung cancer (NSCLC).
- Anatomic lung resection remains a cornerstone of multimodal therapy for NSCLC.
- Increased use of neoadjuvant therapy raises questions about perioperative safety and surgical resectability.
Purpose of the Study:
- To review current data on perioperative safety after neoadjuvant chemo-immunotherapy for NSCLC.
- To discuss surgical technique, resection extent, and intraoperative challenges in this context.
Main Methods:
- Literature review of perioperative safety and surgical outcomes.
- Analysis of clinical case reports illustrating intraoperative challenges.
Main Results:
- Neoadjuvant chemo-immunotherapy has demonstrated improved treatment options for resectable NSCLC.
- Data on perioperative safety, adverse events, and technical resectability are emerging.
- Clinical cases highlight specific surgical considerations and challenges.
Conclusions:
- Neoadjuvant chemo-immunotherapy is a valuable treatment modality for resectable NSCLC.
- Careful consideration of perioperative safety and surgical technique is crucial.
- Further research is needed to fully understand long-term outcomes and optimize surgical management.
