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Intestinal Parasitic Infections May Be Overlooked Drivers of the Tuberculosis Pandemic
Lili B Steel1, Prakash Babu Narasimhan2, Megha Chaudhari3
1Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
The American Journal of Tropical Medicine and Hygiene
|August 13, 2024
Summary
Parasitic infections may increase tuberculosis (TB) risk and worsen outcomes, particularly in tropical regions. Further research into these coinfections is crucial for effective TB control strategies.
Area of Science:
- Global Health
- Infectious Diseases
- Immunology
Background:
- Tuberculosis (TB) disproportionately affects tropical and subtropical regions.
- These regions commonly experience coinfections with intestinal parasites.
- Geographical overlap suggests a link between TB and intestinal parasitic infections.
Purpose of the Study:
- To review epidemiological and immunological evidence linking parasitic infections to TB.
- To highlight the implications of parasitic coinfections for the TB pandemic.
- To identify knowledge gaps and advocate for research on TB-parasitic coinfections.
Main Methods:
- Perspective review of existing literature.
- Analysis of epidemiological data on TB and parasitic infections.
- Discussion of immunological mechanisms.
Main Results:
- Parasitic infections may increase vulnerability to TB.
- Mechanisms include altered inflammation, undernutrition, and drug pharmacokinetics.
- Evidence suggests worse TB treatment outcomes in coinfected individuals.
Conclusions:
- Intestinal parasitic infections represent a potential widespread comorbidity of TB.
- Increased research is needed to understand and address TB-parasitic coinfections.
- Addressing this comorbidity is essential for global TB control efforts.
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