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The weekend warrior effect: Consistent intermittent exercise induces persistent cognitive benefits.

Scott La Tour1, Hassan Shaikh1, Joy H Beardwood1

  • 1Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory (CNLM), University of California Irvine, Irvine, CA 92697, USA.

Neurobiology of Learning and Memory
|August 13, 2024
PubMed
Summary
This summary is machine-generated.

Consistent intermittent exercise, like the "weekend warrior" effect, enhances long-term memory and cognitive function. This exercise pattern shows lasting benefits for hippocampus-dependent memory, unlike continuous exercise.

Keywords:
ACVR1CBDNFCognitive BenefitContinuous ExerciseHippocampusIntermittent ExerciseLong Term MemoryMemoryObject Location MemoryWeekend Warrior

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Area of Science:

  • Neuroscience
  • Exercise Physiology
  • Cognitive Science

Background:

  • Exercise offers significant cognitive benefits, particularly for memory.
  • Previous studies showed 14 days of continuous exercise improved hippocampus-dependent Object Location Memory (OLM) in mice.
  • The cognitive effects of intermittent exercise remain largely unexplored.

Purpose of the Study:

  • To investigate if intermittent exercise (weekend warrior effect) provides similar or different cognitive benefits compared to continuous exercise.
  • To determine the persistence of cognitive benefits from intermittent exercise.
  • To explore the molecular mechanisms underlying exercise-induced memory enhancement.

Main Methods:

  • Adult mice underwent intermittent exercise (2 days/week for 7 weeks) or continuous exercise (14 days).
  • Object Location Memory (OLM) task was used to assess hippocampus-dependent learning and memory.
  • Gene expression analysis of Acvr1c and Bdnf in the dorsal hippocampus was performed.

Main Results:

  • Both continuous and intermittent exercise enabled hippocampus-dependent OLM compared to controls.
  • Intermittent exercise led to sustained cognitive benefits after a 7-day sedentary period, unlike continuous exercise.
  • Intermittent exercise upregulated Acvr1c and Bdnf gene expression in the dorsal hippocampus compared to continuous exercise.

Conclusions:

  • Consistent intermittent exercise persistently enhances hippocampus-dependent long-term memory.
  • Intermittent exercise may offer more durable cognitive benefits than continuous exercise.
  • Understanding exercise parameters and molecular mechanisms can aid in mitigating cognitive decline.