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Herb-antitumour drug interaction risks: retrospective integrative oncology study
Noah Samuels1,2, Shir Shapira2, Eran Ben-Arye3,4
1Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel noahs@szmc.org.il.
Oncology patients frequently use herbal medicines, but predicting herb-drug interactions with anticancer drugs is challenging due to limited online data. Further research is needed for informed patient care decisions.
Area of Science:
- Pharmacology
- Oncology
- Integrative Medicine
Background:
- Herbal medicine use is common in cancer patients.
- Potential for negative interactions between herbal products and anticancer drugs exists.
- Assessing herb-drug interaction risk is crucial for patient safety.
Purpose of the Study:
- Identify herbal products used by oncology patients.
- Assess the risk of herb-drug interactions.
- Evaluate the reliability of online resources for interaction information.
Main Methods:
- Surveyed 42 oncology patients on herbal medicine use.
- Identified potential herb-drug interactions using four online databases.
- Assessed interaction risk using the KNMP scoring system.
Main Results:
- 62% of patients used herbal medicines (70 products identified).
- Nine potential herb-drug interactions were found; only one had a significant KNMP score.
- Online resources provided limited and inconsistent interaction information.
Conclusions:
- Predicting herb-drug interactions is difficult due to data limitations.
- Clinical implications of these interactions require further investigation.
- Informed decision-making for patients and providers is essential.
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