Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy
Zdeněk Kejík1,2, Jan Hajduch3,4, Nikita Abramenko3,4
1BIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic. Zdenek.Kejik@lf1.cuni.cz.
Abstract:
Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show significant potential in enhancing PDT and PTT. The potential and limitations of cyanine dyes for mitochondrial PDT and PTT are discussed, along with their applications in combination therapies, theranostic techniques, and optimal delivery systems. Additionally, novel approaches for sonodynamic therapy using photoactive cyanine dyes are presented, highlighting advances in cancer treatment.
Insights
Cyanine dyes target cancer cell mitochondria, enhancing photodynamic and photothermal therapies (PDT and PTT). These dyes offer innovative, non-invasive treatment strategies and show promise in advanced cancer therapies.
Area of Science:
- Biomedical Engineering
- Oncology
- Materials Science
Background:
- Mitochondrial dysregulation is crucial in cancer development.
- Mitochondria targeting is key for effective cancer therapy.
- Photodynamic and photothermal therapies (PDT and PTT) are promising non-invasive treatments.
Purpose of the Study:
- To review the potential and limitations of cyanine dyes for mitochondrial PDT and PTT.
- To explore applications of cyanine dyes in combination therapies and theranostics.
- To present novel sonodynamic therapy approaches using photoactive cyanine dyes.
Main Methods:
- Literature review focusing on cyanine dyes in cancer therapy.
- Analysis of dye properties, including mitochondrial selectivity and therapeutic efficacy.
- Discussion of delivery systems and combination strategies.
Main Results:
- Cyanine dyes exhibit strong mitochondrial selectivity, enhancing PDT and PTT efficacy.
- These dyes show potential in theranostic applications and combination treatments.
- Novel sonodynamic therapy applications using photoactive cyanine dyes are emerging.
Conclusions:
- Cyanine dyes are valuable tools for mitochondrial-targeted cancer therapies.
- Further research into optimized delivery and combination strategies is warranted.
- Cyanine dye-based therapies represent a significant advance in non-invasive cancer treatment.
