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Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...

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Related Experiment Video

Updated: Jun 17, 2025

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Published on: June 17, 2015

Correction: Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems

Mehtap Bacioglu¹, Manuel Schweighauser², Derrick Gray³

¹Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Acta Neuropathologica Communications

|August 13, 2024

Summary

No abstract available in PubMed .

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Last Updated: Jun 17, 2025

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

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