Nanozyme-Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Catalysis

Background:

• Nanozymes are nanoscale materials mimicking natural enzymes, offering advantages like low cost and robust activity.
• Their catalytic properties enable applications in sensing, remediation, and theranostics.
• Nanozymes are emerging as powerful labels for biomedical diagnosis due to signal amplification.

Purpose of the Study:

• To provide a comprehensive overview of nanozyme applications in biomedical diagnosis.
• To summarize nanozyme synthesis and strategies for enhancing catalytic activity and specificity.
• To review the use of nanozymes in detecting various diseases and biomarkers.

Main Methods:

• Review of synthesis methods for nanozyme materials.
• Discussion of strategies to improve nanozyme catalytic activity and specificity.
• Analysis of nanozyme applications in diagnosing metabolic, cardiovascular, nervous, digestive diseases, and cancers.

Main Results:

• Nanozymes demonstrate significant potential as diagnostic labels.
• Successful application in detecting biomarkers across diverse disease categories.
• Advancements in enhancing nanozyme catalytic efficiency and target specificity.

Conclusions:

• Nanozymes are promising tools for advanced biomedical diagnosis.
• Further research is needed to address challenges and optimize nanozyme-based diagnostic platforms.
• Future trends focus on improving sensitivity, specificity, and clinical translation.