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Bombesin effects on human GI functions.

G Delle Fave, B Annibale, L de Magistris

    Peptides
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Amphibian peptide Bombesin (BBS) significantly impacts human digestion by increasing esophageal pressure, slowing gastric emptying, and affecting gallbladder and intestinal activity. It also stimulates gastric acid and pancreatic secretions, including insulin and glucagon.

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Peptide Science

    Background:

    • Bombesin (BBS), a peptide from amphibian skin, is known to have physiological effects.
    • Its specific actions on human gastrointestinal and pancreatic functions require detailed review.

    Purpose of the Study:

    • To review the diverse actions of Bombesin (BBS) on human gastrointestinal and pancreatic functions.
    • To consolidate current understanding of BBS's physiological impact in humans.

    Main Methods:

    • Review of existing literature on Bombesin (BBS) effects.
    • Analysis of studies detailing BBS administration in human subjects.

    Main Results:

    • BBS increases lower esophageal sphincter pressure and delays gastric emptying.

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  • It inhibits duodenal and jejunal motility, affects gallbladder emptying, and stimulates gastric acid secretion.
  • BBS induces release of insulin, glucagon, pancreatic polypeptide, and pancreatic enzymes, and stimulates bicarbonate secretion.

    • Conclusions:

    • Bombesin (BBS) exerts significant regulatory control over multiple human gastrointestinal and pancreatic functions.
    • These findings highlight BBS as a key peptide influencing digestive and endocrine processes.