Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.9K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
3.9K
Hematopoiesis01:21

Hematopoiesis

5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Production of Formed Elements01:34

Production of Formed Elements

1.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Iron deficiency anemia in elderly and senile patients.]

Advances in gerontology = Uspekhi gerontologii·2021
Same author

Role of molecular-genetic abnormalities in pathogenesis and risk stratification of multiple myeloma.

Voprosy onkologii·2018
Same author

Chiral Surface Twists and Skyrmion Stability in Nanolayers of Cubic Helimagnets.

Physical review letters·2016
Same author

Three-dimensional chiral skyrmions with attractive interparticle interactions.

Journal of physics. Condensed matter : an Institute of Physics journal·2016
Same author

[ANEMIC SYNDROME AND ITS SPECIFICS IN SENIOR PATIENTS].

Advances in gerontology = Uspekhi gerontologii·2015
Same author

Theory of skyrmion states in liquid crystals.

Physical review. E, Statistical, nonlinear, and soft matter physics·2014

Related Experiment Video

Updated: Jun 17, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

12.4K

[Aging and clonal hematopoesis.]

A N Bogdanov1,2, S V Voloshin3,4,5, E O Kunevich3

  • 1Saint-Petersburg State University, 7-9 University embankment, St. Petersburg 199034, Russian Federation,

Advances in Gerontology = Uspekhi Gerontologii
|August 14, 2024
PubMed
Summary
This summary is machine-generated.

Aging increases somatic mutations, leading to clonal hematopoiesis of indeterminate potential (CHIP). CHIP, common in the elderly, signifies mutations in blood cells and is linked to health risks.

Keywords:
DNA methylationagingclonal hematopoiesisepigenetic clockshematopoietic stem cellsomatic mutations

More Related Videos

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.1K
Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

1.7K

Related Experiment Videos

Last Updated: Jun 17, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

12.4K
Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.1K
Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

1.7K

Area of Science:

  • Genetics and Epigenetics
  • Aging Research
  • Hematology

Background:

  • Somatic mutations accumulate with age across tissues, notably in hematopoietic stem cells (HSCs).
  • Clonal hematopoiesis, characterized by the expansion of mutated HSCs, is prevalent in the elderly.
  • Clonal hematopoiesis of indeterminate potential (CHIP) involves somatic mutations in blood cells without malignancy.

Purpose of the Study:

  • To explore the role of clonal hematopoiesis and CHIP in aging and disease development.
  • To investigate the association between epigenetic aging, CHIP, and adverse health outcomes.
  • To understand the implications of CHIP as an independent risk factor for various diseases.

Main Methods:

  • Analysis of age-related somatic mutations in hematopoietic stem cells.
  • Definition and identification of Clonal Hematopoiesis of Indeterminate Potential (CHIP).
  • Correlation of epigenetic aging markers with CHIP prevalence and health outcomes.

Main Results:

  • CHIP is a common phenomenon in the elderly, associated with mutations in genes like DNMT3A and TET2.
  • CHIP is an independent risk factor for hematological malignancies, cardiovascular diseases, and mortality.
  • The combination of epigenetic aging and CHIP is linked to adverse health outcomes.

Conclusions:

  • CHIP represents a significant aging-related phenomenon with broad health implications.
  • Epigenetic aging combined with CHIP indicates increased health risks.
  • Further research is needed to explore CHIP's role in disease and potential interventions.