Lower Visceral Fat is Related to Diabetic Peripheral Neuropathy

Area of Science:

• Endocrinology
• Diabetology
• Neurology

Background:

• Visceral fat area (VFA) is associated with insulin resistance, metabolic syndrome, and diabetes complications.
• Diabetic neuropathy, including peripheral neuropathy, is a significant complication of type 2 diabetes (T2DM).

Purpose of the Study:

• To investigate the correlation between visceral fat area (VFA) and peripheral neuropathy in patients with type 2 diabetes (T2DM).

Main Methods:

• Retrospective analysis of 488 T2DM patients, divided into groups with and without peripheral neuropathy.
• Correlation and multiple logistic regression analyses were used to assess the relationship between VFA and diabetic peripheral neuropathy (DPN).

Main Results:

• Patients with peripheral neuropathy had lower VFA, longer diabetes duration, and higher FPG and HbA1c levels compared to controls.
• Spearman correlation showed a negative correlation between VFA and peripheral neuropathy.
• Logistic regression identified VFA, diabetes duration, and HbA1c as influencing factors for peripheral neuropathy in T2DM.

Conclusions:

• A correlation exists between visceral fat and peripheral neuropathy in T2DM patients.
• Monitoring VFA is important in managing T2DM patients due to its association with neuropathy.
• Lower VFA, longer diabetes duration, and elevated HbA1c are linked to peripheral neuropathy in T2DM.