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Updated: Jul 11, 2026
12:16
Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
Published on: December 17, 2015
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Current research progress on Prevotella intermedia and associated diseases
Shuyang Zhang1,2, Yuheng Zhao3, Jonathan Lalsiamthara4
1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.
Critical Reviews in Microbiology
|August 14, 2024
Summary
Prevotella intermedia, a common periodontitis pathogen, is linked to systemic diseases. Its virulence factors enable invasion and immune interference, contributing to various illnesses.
Area of Science:
- Microbiology
- Immunology
- Pathogenesis
Background:
- Prevotella intermedia is a Gram-negative anaerobic bacterium frequently implicated in periodontitis.
- Emerging research indicates a strong association between P. intermedia and diseases affecting multiple organ systems.
- The bacterium possesses virulence factors, including cysteine protease and adhesins, that facilitate host cell interaction.
Purpose of the Study:
- To review current research on Prevotella intermedia virulence factors.
- To explore the bacterial pathogenesis mechanisms of P. intermedia.
- To summarize the correlation between P. intermedia and diverse systemic diseases.
Main Methods:
- Literature review of scientific articles.
- Analysis of studies on bacterial virulence factors.
- Synthesis of research on P. intermedia's role in disease.
Main Results:
- P. intermedia utilizes virulence factors to bind and invade host cells like gingival fibroblasts.
- The bacterium can promote the growth of other pathogenic bacteria, disrupting immune responses.
- P. intermedia's actions contribute to the development and progression of various inflammatory diseases.
Conclusions:
- Prevotella intermedia's virulence factors are key to its pathogenic potential.
- Understanding P. intermedia's pathogenesis is crucial for addressing associated systemic diseases.
- Further research is needed to fully elucidate the bacterium's role in multi-systemic pathology.
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