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Executive function and cortical thickness in biomarker aMCI
David M Scarisbrick1,2,3, Cierra M Keith1,2,3, Camila Vieira Ligo Teixeira1
1Rockefeller Neuroscience Institute Innovation Center Clinic, Morgantown, WV, USA.
Introduction:
Memory deficits are the primary symptom in amnestic Mild Cognitive Impairment (aMCI); however, executive function (EF) deficits are common. The current study examined EF in aMCI based upon amyloid status (A+/A-) and regional atrophy in signature areas of Alzheimer's disease (AD).
Method:
Participants included 110 individuals with aMCI (A+ = 66; A- = 44) and 33 cognitively healthy participants (HP). EF was assessed using four neuropsychological assessment measures. The cortical thickness of the AD signature areas was calculated using structural MRI data.
Results:
A + had greater EF deficits and cortical atrophy relative to A - in the supramarginal gyrus and superior parietal lobule. A - had greater EF deficits relative to HP, but no difference in signature area cortical thickness.
Discussion:
The current study found that the degree of EF deficits in aMCI are a function of amyloid status and cortical thinning in the parietal cortex.
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