LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans
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View abstract on PubMed
Summary
This summary is machine-generated.Liver-expressed antimicrobial peptide 2 (LEAP2) is higher in individuals with overweight or obesity and is linked to feeding behaviors. LEAP2 levels decrease after a high-protein meal, particularly in women, suggesting a role in appetite regulation.
Area Of Science
- Endocrinology and Metabolism
- Human Physiology
- Genetics
Background
- Liver-expressed antimicrobial peptide 2 (LEAP2) plays a role in innate immunity and metabolic regulation.
- Understanding LEAP2 dynamics in human plasma, especially concerning feeding behavior and body weight, is crucial for metabolic health research.
Purpose Of The Study
- To investigate fasting LEAP2 levels in normal weight versus overweight/obese individuals.
- To examine the associations between LEAP2 and anthropometric, metabolic, and behavioral factors, including genetics and DNA methylation.
- To assess postprandial LEAP2 changes after a high-protein meal and their relation to food intake and feeding behavior.
Main Methods
- Plasma LEAP2 concentrations, anthropometric measures, and behavioral traits were assessed in 327 participants.
- Genotyping and methylation profiling were performed.
- A subgroup (n=123) underwent a high-protein meal test with postprandial LEAP2 and behavioral assessments.
Main Results
- Higher LEAP2 concentrations were observed in individuals with overweight/obesity and in females.
- LEAP2 levels correlated with specific LEAP2 genetic variants (rs765760, rs803223) but not DNA methylation.
- In normal weight individuals, LEAP2 associated with glycemia and fullness; in overweight/obese individuals, it linked to BMI, waist circumference, and impulsivity. LEAP2 was inversely associated with food intake and decreased post-meal, especially in women.
Conclusions
- Elevated LEAP2 in overweight/obese individuals is linked to obesity-related behavioral characteristics.
- Sexual dimorphism in LEAP2 concentration was observed both pre- and post-meal.
- LEAP2 appears to play a significant role in regulating feeding behavior and appetite control.
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