Related Experiment Video
Updated: Jun 17, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Review on Catalytic Meinwald Rearrangement of Epoxides
Yulong Zhang1, Bowen Hu2, Yushuang Chen2
1Chongqing Key Laboratory of Green Synthesis and Application, College of Chemistry, Chongqing Normal University, Chongqing, 401331, People's Republic of China.
Abstract:
The past few decades have witnessed tremendous development within epoxides. Among the many known reactions involving epoxide, Meinwald rearrangements represent one of the most important and attractive approaches, which can transform epoxides into versatile carbonyl compounds. Given the high efficiency of this protocol, substantial efforts have been made by researchers by utilizing multiple catalyst systems. This review provides an overview of recent advances in the Meinwald rearrangement (from 2014 onward), along with detailed discussions on mechanistic insights. This review aims to highlight the importance and value of these methodologies, thereby promoting further investigation and application.
Related Concept Videos
Acid-Catalyzed Ring-Opening of Epoxides
Preparation of Epoxides
Epoxides result from alkene oxidation, which can be achieved by a) air, b) peroxy acids, c) hypochlorous acids, and d) halohydrin cyclization.
Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of...
Base-Catalyzed Ring-Opening of Epoxides
Sharpless Epoxidation
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement

