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Infections after transplantation of a contaminated kidney
Abstract:
In a retrospective study of 350 consecutive cadaver renal transplants, at least 83 (24%) of the donor kidneys were found to be contaminated. This was associated with three perinephric abscesses, one mycotic aneurysm, one pseudomonas sepsis, and four superficial wound infections. As a result, three patients lost their grafts, and one patient died from septic complications. The one year graft survival of the remainder of the recipients of contaminated grafts did not differ from that of the whole series. It is concluded that contamination of donor kidneys is a frequent event, but serious complications are relatively rare.
Insights
Donor kidney contamination is common in renal transplants, affecting 24% of kidneys. While serious complications like graft loss and death can occur, they are rare, and overall graft survival remains unaffected.
Area of Science:
- Nephrology
- Transplant Surgery
- Infectious Diseases
Background:
- Donor kidney contamination is a potential risk in renal transplantation.
- Assessing the impact of contamination on transplant outcomes is crucial.
Purpose of the Study:
- To determine the incidence of donor kidney contamination in cadaver renal transplants.
- To evaluate the association between donor kidney contamination and post-transplant complications and graft survival.
Main Methods:
- Retrospective analysis of 350 consecutive cadaver renal transplants.
- Documentation of donor kidney contamination rates.
- Tracking of post-transplant infectious complications and graft outcomes.
Main Results:
- At least 24% of donor kidneys were contaminated.
- Contamination was linked to perinephric abscesses, mycotic aneurysm, sepsis, and wound infections.
- Three patients lost grafts, and one died; however, one-year graft survival for recipients of contaminated kidneys was similar to the overall series.
Conclusions:
- Donor kidney contamination is a frequent occurrence in renal transplantation.
- Serious infectious complications are rare despite high contamination rates.
- Contamination does not significantly impact long-term graft survival.