Precision therapy for cancer prevention by targeting carcinogenesis

Area of Science:

• Oncology
• Preventive Medicine
• Genetics

Background:

• Cancer poses a significant global health challenge, with projected increases in new cases.
• Primary cancer prevention is crucial for reducing the societal and economic burden of the disease.
• While some cancers have clear preventive measures (e.g., tobacco bans, HPV vaccination), many lack practical primary prevention due to unclear or uncontrollable causes.

Purpose of the Study:

• To review advancements in precision therapy for cancer prevention.
• To focus on targeting the entire carcinogenesis process.
• To identify and discuss strategies for three specific high-risk groups.

Main Methods:

• Review of current research on precision cancer prevention.
• Identification of high-risk populations for targeted interventions.
• Analysis of therapeutic approaches for chronic inflammation, germline mutations, and precancerous lesions.

Main Results:

• Precision therapy offers a promising approach to cancer prevention by targeting the underlying mechanisms of carcinogenesis.
• Interventions for individuals with chronic inflammation, inherited germline mutations, and precancerous lesions are key areas of focus.
• Attenuating inflammation, treating precancerous conditions, and managing high-risk tissues are identified as effective precision prevention methods.

Conclusions:

• Precision medicine can be applied to cancer prevention, particularly for high-risk individuals.
• Targeting chronic inflammation, germline mutations, and precancerous lesions represents a proactive approach to cancer prevention.
• These precision strategies hold the potential to significantly reduce cancer incidence and burden.