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Updated: Jun 17, 2025
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A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
Published on: August 14, 2013
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Trastuzumab-induced optic neuritis: "blindness" side effect
1Dr Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey.
Summary
Trastuzumab, a breast cancer treatment, can cause acute vision loss due to optic neuritis. Early detection and management are crucial for patients receiving this therapy.
Area of Science:
- Oncology
- Ophthalmology
- Pharmacology
Background:
- Trastuzumab is a targeted therapy that has improved outcomes for HER2-positive breast cancer.
- Adverse events associated with trastuzumab therapy require careful monitoring.
Purpose of the Study:
- To report a case of severe vision loss secondary to optic neuritis in a patient treated with trastuzumab.
- To highlight the potential for trastuzumab-induced optic neuropathy.
Main Methods:
- A case report of a 60-year-old female with HER2-positive breast cancer undergoing treatment with trastuzumab.
- Clinical presentation, diagnostic workup, and treatment course for vision loss were documented.
Main Results:
- The patient experienced progressive vision loss after initiating adjuvant trastuzumab therapy.
- Despite treatment with pulse steroids and discontinuation of trastuzumab, visual acuity remained severely impaired.
Conclusions:
- Trastuzumab-induced optic neuritis is a rare but serious adverse event.
- Clinicians should be vigilant for visual disturbances in patients receiving trastuzumab and consider early intervention.
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