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Updated: Jun 17, 2025
07:49
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
124
A bibliometric and citation network analysis of crosslinking
Miguel Ángel Sánchez-Tena1, Clara Martínez Pérez2, Cesar Villa-Collar3
1Optometría y Vision, Complutense University of Madrid Faculty of Optics and Optometry, Madrid, Comunidad de Madrid, Spain.
European Journal of Ophthalmology
|August 14, 2024
Summary
This bibliometric analysis reveals key research trends in ocular crosslinking. While keratoconus treatment remains central, recent studies increasingly explore crosslinking
Area of Science:
- Ophthalmology and Cornea Research
- Biomedical Engineering and Material Science
Background:
- Ocular crosslinking research primarily targets slowing keratoconus progression.
- Bibliometric analysis is crucial for understanding research landscapes and author collaborations.
Purpose of the Study:
- To map the publication and author relationships in ocular crosslinking research.
- To identify and categorize the diverse research areas within ocular crosslinking.
Main Methods:
- Bibliometric analysis of publications from 1972-2023 sourced from Web of Science.
- Utilized search terms including 'crosslinking', 'cornea', 'ectasia', and 'Keratoconus'.
- Employed CitNetExplorer, VOSviewer, and CiteSpace for data analysis and visualization.
Main Results:
- Identified 7161 publications and 59415 citation networks, with a peak in 2021.
- The most cited work is Wollensak et al. (2003) on riboflavin/UVA-induced crosslinking for keratoconus.
- Clustering revealed five main research areas: keratoconus, corneal transplantation, cataracts, inflammation, and axial growth.
Conclusions:
- Keratoconus treatment remains the predominant research focus in ocular crosslinking.
- A notable recent increase in research investigates crosslinking's role in mitigating axial growth.
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