Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathogenesis and management of abnormal puberty.

N J Hopwood

    Special Topics in Endocrinology and Metabolism
    |January 1, 1985
    PubMed
    Summary

    Understanding abnormal puberty in children is key. The hypothalamic-pituitary-gonadal (H-P-G) axis regulates development, and disruptions can cause precocious or delayed puberty, requiring specific diagnostic and management strategies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Array comparative genomic hybridisation analysis of boys with X linked hypopituitarism identifies a 3.9 Mb duplicated critical region at Xq27 containing SOX3.

    Journal of medical genetics·2004
    Same author

    The dilemma of the short child without a clear diagnosis.

    Pediatric annals·2000
    Same author

    Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene.

    The New England journal of medicine·1998
    Same author

    Persistent hypothyroidism in an infant receiving a soy formula: case report and review of the literature.

    Pediatrics·1995
    Same author

    Growth hormone bioactivity in girls with Turner's syndrome: correlation with insulin-like growth factor I.

    Pediatric research·1994
    Same author

    Thyroid masses: approach to diagnosis and management in childhood and adolescence.

    Pediatrics in review·1993

    Area of Science:

    • Pediatric Endocrinology
    • Reproductive Medicine
    • Human Physiology

    Background:

    • The prepubertal hypothalamic-pituitary-gonadal (H-P-G) axis is highly sensitive to negative feedback from sex steroids.
    • Normal puberty involves increased pulsatile secretion of gonadotropin-releasing hormone (GnRH), leading to gonadal stimulation and maturation.
    • Malfunctions in the H-P-G axis can result in abnormal pubertal development, including precocious or delayed puberty.

    Purpose of the Study:

    • To outline the mechanisms of normal pubertal development.
    • To differentiate various types of abnormal puberty (precocious and delayed).
    • To discuss diagnostic tools and management strategies for abnormal puberty.

    Main Methods:

    • Review of the physiological regulation of the H-P-G axis.
    • Classification of precocious puberty (isosexual, heterosexual, complete, partial, intermittent, progressive).
    • Identification of diagnostic methods like cranial axial tomography, GnRH response testing, and pelvic ultrasound.
    • Evaluation of causes for delayed puberty and gonadal failure.

    Main Results:

    • True precocious puberty is progressive and hormonally indicative of normal puberty at an earlier age.
    • Intermittent precocious puberty is often self-limited, while precocious pseudopuberty involves tumors.
    • Delayed puberty can be due to maturation lag or underlying conditions like chronic illness or gonadal failure.

    Conclusions:

    • Accurate diagnosis of abnormal puberty relies on understanding H-P-G axis function and utilizing specific tests.
    • GnRH analogues are effective for managing true progressive central precocious puberty.
    • Management of delayed puberty involves addressing underlying causes and hormone replacement therapy when indicated.

    Related Experiment Videos