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Related Experiment Videos

Tear analysis in contact lens wearers.

R L Farris

    Transactions of the American Ophthalmological Society
    |January 1, 1985
    PubMed
    Summary

    Contact lens wear did not significantly alter tear composition (albumin, lysozyme, lactoferrin). However, aphakic patients without lenses showed elevated tear osmolarity, suggesting potential ocular surface changes.

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    Area of Science:

    • Ophthalmology
    • Biochemistry
    • Contact Lens Technology

    Background:

    • Tear film analysis is crucial for understanding ocular surface health.
    • Contact lens wear can potentially alter tear film composition and properties.
    • Aphakia, the absence of a lens, presents unique physiological conditions.

    Purpose of the Study:

    • To compare tear analysis in contact lens wearers with aphakic and phakic non-wearers.
    • To investigate the impact of different contact lens types on tear osmolarity and protein concentrations.
    • To assess tear film changes in relation to aphakia and lens wear.

    Main Methods:

    • Tear osmolarity, albumin, lysozyme, and lactoferrin were measured in basal and reflex tears.
    • Five subject groups were analyzed: aphakic non-wearers, phakic daily-wear hard/soft lens wearers, and phakic/aphakic extended-wear soft lens wearers.
    • Statistical comparison using Student's t-test against age- and sex-matched controls.

    Main Results:

    • Significant elevation in tear osmolarity observed in aphakic subjects without contact lenses.
    • Minor tear osmolarity differences noted in phakic subjects with hard daily-wear or extended-wear soft lenses.
    • No significant differences in tear albumin, lysozyme, or lactoferrin concentrations across groups.

    Conclusions:

    • Contact lens wear, regardless of type, did not significantly alter tear protein levels (albumin, lysozyme, lactoferrin).
    • Individual variations in tear proteins may mask differences related to contact lens wear.
    • Aphakia and older age may correlate with a tendency for increased tear protein concentrations.

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