Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Drug discrimination: methodology and current problems].

S Watanabe

    Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices: protection by 5-HT1A receptor agonists and 5-HT2 receptor antagonists.

    European journal of pharmacology·1992
    Same author

    Effect of substance P on circadian rhythms of firing activity and the 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro.

    Brain research·1992
    Same author

    Cancer mortality trends in Japan 1960-1990: three-dimensional graphical presentation.

    Japanese journal of clinical oncology·1992
    Same author

    Effect of time of day on adaptive response to a 4-week aerobic exercise program.

    The Journal of sports medicine and physical fitness·1992
    Same author

    [A case of hepatic hydrothorax treated by pleuro-venous shunt].

    Kyobu geka. The Japanese journal of thoracic surgery·1992
    Same author

    Type 3 GM1 gangliosidosis: characteristic MRI findings correlated with dystonia.

    Acta neurologica Scandinavica·1992
    Same journal

    [Proceedings of the 23rd Annual Meeting of the Japanese Society of Neuropsychopharmacology. September 28-29, 1993. Abstracts].

    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology·1993
    Same journal

    Effects of long-term treatment of haloperidol on D2 dopamine receptors in various areas of rat brain.

    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology·1993
    Same journal

    MK-801 and dopaminergic system in electrically-induced convulsions in mice.

    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology·1993
    Same journal

    [A study on the pharmacological mechanism of the mood stabilizer--the changes of the rat brain concentrations of monoamines and their metabolites after the administration of Li, CBZ and VPA for 14 days].

    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology·1993
    Same journal

    [Recent advances in neuropharmacology of the centrally acting antitussive drugs].

    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology·1993
    Same journal

    [Cocaine toxicity, enhancing effects in grouped mice and mechanism on behavioral characteristics].

    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology·1993
    See all related articles

    Drug discrimination experiments reveal complex stimulus properties, where dose changes can alter subjective drug quality and individual responses vary. This research clarifies drug action sites and similarities.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Drug discrimination experiments are crucial for understanding how drugs affect the central nervous system.
    • Characterizing drug stimulus properties is essential for pharmacology and drug development.

    Purpose of the Study:

    • To quantitatively and qualitatively describe the stimulus properties of drugs.
    • To identify the site of drug action (central vs. peripheral) and the active substance (drug or metabolite).
    • To measure drug similarity, antagonism, and understand generalization patterns.

    Main Methods:

    • Utilizing drug discrimination paradigms to assess stimulus properties.
    • Analyzing dose-response relationships to understand intensity and quality changes.
    • Investigating drug generalization to identify similarities and differences between substances.

    Related Experiment Videos

    Main Results:

    • Drug stimulus properties are not always dose-dependent in intensity, with varying subjective qualities at different doses.
    • Drugs can act as compound stimuli, leading to asymmetric generalization and individual differences in response.
    • Tolerance, species differences, and the relationship between stimulus properties and other drug effects were observed.

    Conclusions:

    • Drug discrimination provides a powerful tool for characterizing complex drug stimulus properties.
    • Understanding stimulus control is key to explaining drug generalization, individual variability, and drug effects.
    • This research contributes to a deeper understanding of drug action mechanisms and pharmacological profiles.