![Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F61682.jpg&w=3840&q=50)
Longitudinal analysis of serum urate in prediabetic phase
Javier Marrugo1,2,3, Leah M Santacroce1, Misti L Paudel1,3
1Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rheumatology (Oxford, England)
|August 14, 2024
Summary
Serum urate (SU) levels increase over time in individuals with prediabetes. Factors like older age, male sex, higher BMI, and elevated HbA1c predict these rising SU levels, suggesting early intervention opportunities.
Area of Science:
- Endocrinology and Metabolism
- Nephrology
- Rheumatology
Background:
- Prediabetes is linked to hyperuricemia, but serum urate (SU) trends during this phase are not well understood.
- Understanding SU changes in prediabetes is crucial for potential early interventions.
Purpose of the Study:
- To assess the longitudinal changes in serum urate (SU) levels among individuals diagnosed with prediabetes.
- To identify predictors of increasing SU levels during the prediabetic period.
Main Methods:
- Retrospective cohort study using electronic health records (2007-2022) of individuals with prediabetes (HbA1c 5.7%-6.4%).
- Included patients with at least one SU test before and after prediabetes diagnosis.
- Multivariable mixed-effects models estimated SU trends, censoring at diabetes onset. Subgroup analyses were performed.
Main Results:
- 1521 individuals with prediabetes met SU cohort criteria, with 6832 SU observations over a median 7.4-year follow-up.
- Higher baseline SU levels were observed in individuals with a BMI ≥30 kg/m2.
- Older age, male sex, greater BMI, and higher HbA1c were significant predictors of increased longitudinal SU levels.
Conclusions:
- Baseline characteristics such as age, sex, BMI, and HbA1c predict increasing serum urate levels in prediabetes.
- These findings support the potential for early interventions during the prediabetic phase to manage SU levels and possibly reduce gout risk.
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