Altered lipidomics biosignatures in schizophrenia: A systematic review

Area of Science:

• Neuroscience
• Biochemistry
• Genomics

Background:

• Schizophrenia is a complex neuropsychiatric disorder with identified molecular signatures.
• Lipid dysregulation is a recurring observation in schizophrenia pathobiology.
• Lipidomics is an emerging tool for studying these lipid profiles.

Purpose of the Study:

• To review and synthesize findings from human lipidomics studies in schizophrenia.
• To identify common lipidomics patterns in both brain and peripheral samples.
• To highlight current limitations and future directions in schizophrenia lipidomics research.

Main Methods:

• Comprehensive literature search for lipidomics studies in schizophrenia.
• Inclusion/exclusion criteria focused on human studies using brain and blood specimens (serum, plasma, platelets, red blood cells).
• Analysis of 18 selected studies (5 brain, 12 peripheral, 1 both).

Main Results:

• Review of lipidomics data from 18 human studies on schizophrenia.
• Identification of lipidomics patterns in brain and peripheral tissues.
• Synthesis of findings on lipid dysregulation in schizophrenia.

Conclusions:

• Lipidomics offers valuable insights into schizophrenia pathobiology.
• Consistent lipidomics patterns are emerging across brain and peripheral studies.
• Further research integrating lipidomics with complementary approaches is needed.