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Airway bacterial microbiome signatures correlate with occupational pneumoconiosis progression

Huimin Ma1, Zheng Dong2, Xu Zhang3

  • 1Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; Department of Stomatology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.

Ecotoxicology and Environmental Safety
|August 14, 2024
PubMed

Insights

Occupational pneumoconiosis (OP) patients show altered respiratory bacterial communities, potentially linked to particulate matter (PM) exposure. Specific bacteria may serve as markers for disease progression.

Area of Science:

  • Microbiology
  • Pulmonary Medicine
  • Environmental Health

Background:

  • The human microbiome plays a crucial role in respiratory health and disease.
  • Knowledge gaps exist regarding the link between bacterial communities and particulate matter (PM)-induced respiratory issues.

Purpose of the Study:

  • To characterize the respiratory bacterial microbiome in occupational pneumoconiosis (OP) patients.
  • To investigate the association between respiratory microbiota and PM exposure in OP.

Main Methods:

  • Respiratory samples were collected from different airway sites of OP patients.
  • Bacterial microbiome composition and function were analyzed using sequencing data.
  • Associations between bacterial communities and disease indicators were examined.

Main Results:

  • OP patients displayed distinct respiratory microbiota dysbiosis compared to healthy individuals.
  • Increased colonization by bacteria like Streptococcus was observed, possibly due to PM intrusion.
  • Smoking significantly impacted microbiome alterations in OP patients.

Conclusions:

  • The bacterial microbiome is implicated in the pathogenesis of PM-induced respiratory diseases.
  • Specific bacterial species (Prevotella, Actinobacillus, Leptotrichia) may serve as biomarkers for OP progression.
  • Findings support the development of microbiome-based diagnostics for PM-related disorders.
Keywords:
16S rRNA gene sequencingBacterial microbiomeOccupational pneumoconiosisParticulate mattersRespiratory tract

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