Advances in tumor stroma-based targeted delivery

Area of Science:

• Oncology
• Biomaterials Science
• Pharmacology

Background:

• The tumor stroma significantly influences tumor progression and therapeutic efficacy.
• Interactions within the tumor microenvironment, including the extracellular matrix and stromal cells, are critical.
• Targeted drug delivery systems leveraging tumor stromal components are emerging.

Purpose of the Study:

• To examine the role of tumor stroma in advancing targeted drug delivery systems.
• To review strategies utilizing tumor stromal components for enhanced cancer therapy.
• To highlight the potential of these systems in clinical applications.

Main Methods:

• Review of current literature on tumor stroma-based drug delivery.
• Analysis of strategies employing inherent targeting capabilities of stromal components (e.g., hyaluronic acid, laminin).
• Evaluation of methods focused on modifying the tumor stroma to facilitate drug delivery.

Main Results:

• Tumor stromal components offer inherent targeting capabilities for drug delivery.
• Strategies exist to reshape the tumor stroma, improving drug penetration.
• Emerging drug delivery systems show promise for precise targeting and enhanced safety.

Conclusions:

• Targeted drug delivery systems based on tumor stroma hold significant potential for cancer therapy.
• These systems offer improved precision, penetration, safety, and biocompatibility.
• Further research can deepen understanding of tumor stroma and refine drug delivery strategies.