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Advances in tumor stroma-based targeted delivery

Chunyan Wu1, Yujia Zhai2, Jianbo Ji1

  • 1Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.

International Journal of Pharmaceutics
|August 14, 2024
PubMed

Insights

Tumor stroma components are being utilized for novel targeted drug delivery systems. These systems enhance cancer therapy by improving drug penetration and safety.

Area of Science:

  • Oncology
  • Biomaterials Science
  • Pharmacology

Background:

  • The tumor stroma significantly influences tumor progression and therapeutic efficacy.
  • Interactions within the tumor microenvironment, including the extracellular matrix and stromal cells, are critical.
  • Targeted drug delivery systems leveraging tumor stromal components are emerging.

Purpose of the Study:

  • To examine the role of tumor stroma in advancing targeted drug delivery systems.
  • To review strategies utilizing tumor stromal components for enhanced cancer therapy.
  • To highlight the potential of these systems in clinical applications.

Main Methods:

  • Review of current literature on tumor stroma-based drug delivery.
  • Analysis of strategies employing inherent targeting capabilities of stromal components (e.g., hyaluronic acid, laminin).
  • Evaluation of methods focused on modifying the tumor stroma to facilitate drug delivery.

Main Results:

  • Tumor stromal components offer inherent targeting capabilities for drug delivery.
  • Strategies exist to reshape the tumor stroma, improving drug penetration.
  • Emerging drug delivery systems show promise for precise targeting and enhanced safety.

Conclusions:

  • Targeted drug delivery systems based on tumor stroma hold significant potential for cancer therapy.
  • These systems offer improved precision, penetration, safety, and biocompatibility.
  • Further research can deepen understanding of tumor stroma and refine drug delivery strategies.
Keywords:
Drug deliveryExtracellular matrixMatrix remodelingStromal cellsTargetingTumor stroma

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