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A shape memory cationized chitosan sponge loaded with thrombin for high-effective hemostasis and antibacterial
Ming Ma1, Yi Guo1, Ruotong Ji1
1School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou 510182, China.
International Journal of Biological Macromolecules
|August 14, 2024
Summary
A novel thrombin-loaded cationized chitosan (TCCS) sponge offers potent hemostatic and antibacterial properties. This advanced biomaterial effectively stops bleeding and combats infections, showing great promise for wound management.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Infectious Diseases
Background:
- Severe hemorrhages and bacterial infections pose significant clinical challenges.
- Existing hemostatic agents often lack comprehensive antibacterial properties.
- Chitosan-based materials show promise for wound healing and infection control.
Purpose of the Study:
- To develop and characterize a thrombin-loaded cationized chitosan (TCCS) sponge.
- To evaluate the hemostatic and antibacterial efficacy of the TCCS sponge.
- To assess the biocompatibility and biosafety of the TCCS sponge for potential clinical applications.
Main Methods:
- Multistep preparation of TCCS sponge with porous structure and favorable mechanical properties.
- In vitro assessment of antibacterial activity against Methicillin-resistant Staphylococcus aureus and Escherichia coli.
- In vivo evaluation of hemostatic efficacy using rat tail amputation and liver perforation models.
- Biocompatibility and biosafety testing.
Main Results:
- The TCCS sponge demonstrated excellent water absorption and shape recovery.
- Significant inhibition of bacterial growth was observed for both tested strains.
- The TCCS sponge exhibited superior procoagulant and hemostatic performance compared to commercial hemostats.
- Favorable biocompatibility and biosafety profiles were confirmed.
Conclusions:
- The developed TCCS sponge possesses potent hemostatic and antibacterial capabilities.
- This biomaterial shows significant potential for managing severe bleeding and associated infections.
- The TCCS sponge represents a promising candidate for advanced wound care applications.
