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Updated: Jun 17, 2025

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
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Mitochondrial complex I promotes kidney cancer metastasis

Divya Bezwada1, Luigi Perelli2, Nicholas P Lesner1

  • 1Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature
|August 14, 2024
PubMed
Summary

Kidney cancer cells show altered metabolism, with clear cell renal cell carcinomas (ccRCCs) having suppressed mitochondrial activity. However, ccRCC metastases exhibit increased metabolism, suggesting evolving metabolic programs during cancer progression.

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