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Published on: April 4, 2025
Alzheimer's disease following COVID-19: a two player match?
Raffaella Mormile1, Cristina Mormile2, Carmine Picone3,4
1Division of Pediatrics and Neonatology, Moscati Hospital, Via A. Gramsci, Aversa, 81031, Italy. raffaellamormile@alice.it.
Abstract:
Common pathways may underlie the association between COVID-19 and risk for Alzheimer's disease (AD). We conjecture that severe COVID-19 may contribute to AD onset in predisposed individuals through aberrant MDSCs expression and increased IL-6 expression levels leading to immunosuppression in inflamed brains. Research studies are needed to gain empirical evidence to strengthen the hypothesis of the involvement of MDSCs and IL-6 in the formation of AD following COVID-19 infection and possibly vaccination enabling a more in-depth understanding of the role of immunosuppression in the onset of neurodegenerative diseases at any age. Identifying why those who get severe COVID-19 are more likely to develop AD may offer a novel therapeutic approach to delay or prevent cognitive decline.
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