Related Experiment Video

Updated: Jun 17, 2025

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge
09:32

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge

Published on: January 20, 2023

3.4K

Myocardial strain is regulated by cardiac preload in the early stage of sepsis

Xiaolong Huang1,2, Guiyang Lu1,2, Xiaoyang Cai1,2

  • 1Department of Intensive Care Unit, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.

BMC Cardiovascular Disorders
|August 14, 2024
PubMed

Insights

Fluid resuscitation in sepsis improves myocardial strain, especially in patients with low cardiac preload. Optimizing preload is key to enhancing cardiac function during sepsis treatment.

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Sepsis Research

Background:

  • Sepsis significantly impacts myocardial function.
  • Limited data exists on the relationship between cardiac preload and myocardial strain in sepsis patients.
  • Understanding this relationship is crucial for optimizing fluid management in sepsis.

Purpose of the Study:

  • To investigate the effect of cardiac preload on myocardial strain in patients with sepsis.
  • To analyze the correlation between echocardiographic parameters and preload status.
  • To determine the impact of fluid resuscitation on myocardial strain under varying preload conditions.

Main Methods:

  • Seventy sepsis patients in the ICU underwent transthoracic echocardiography at admission and 24 hours later.
  • Patients were categorized into low left ventricular end-diastolic volume index (LVEDVI) and normal LVEDVI groups.
  • Myocardial strain parameters (LVGLS, LVGCS, RVGLS) and cardiac afterload were assessed and correlated with LVEDVI.

Main Results:

  • Patients with low LVEDVI exhibited faster heart rates and required more fluid resuscitation.
  • Low LVEDVI group showed significant improvements in LVGLS, LVGCS, and RVGLS post-fluid resuscitation.
  • Fluid resuscitation increased cardiac afterload only in the normal LVEDVI group; LVEDVI changes independently predicted strain improvements.

Conclusions:

  • Cardiac preload significantly influences myocardial strain alterations during fluid resuscitation in sepsis.
  • Optimizing preload through fluid management can improve myocardial strain in sepsis patients.
  • LVEDVI is a key indicator for assessing preload responsiveness and guiding fluid therapy in sepsis.
Abstract

Keywords:
Cardiac preloadEchocardiographySepsisStrain

More Related Videos

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

24.1K
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.2K

Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
3.2K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
620
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
771
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K