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Expression of Matrix Metalloproteinase-3 in the Aqueous Humor of Patients with Posner-Schlossman Syndrome

Yu Liu1, Xiangmei Kong2, Jisen Teng1

  • 1Department of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, China.

Current Eye Research
|August 15, 2024
PubMed
Abstract

Insights

Matrix metalloproteinase-3 (MMP-3) levels are significantly elevated in the aqueous humor of patients with Posner-Schlossman syndrome (PSS). This finding suggests MMP-3 plays a key role in PSS development.

Area of Science:

  • Ophthalmology
  • Biochemistry

Background:

  • Posner-Schlossman syndrome (PSS) is a unilateral inflammatory condition characterized by recurrent episodes of elevated intraocular pressure (IOP).
  • The underlying mechanisms of PSS pathogenesis are not fully understood, necessitating further investigation into key molecular players.

Purpose of the Study:

  • To investigate the expression levels of matrix metalloproteinase-3 (MMP-3) in the aqueous humor of patients diagnosed with PSS.
  • To determine the potential association between MMP-3 levels and the clinical characteristics of PSS.

Main Methods:

  • Aqueous humor and peripheral blood samples were collected from 29 PSS patients and 30 age-related cataract (ARC) controls.
  • Matrix metalloproteinase-3 (MMP-3) concentrations in serum and aqueous humor were quantified using immunoturbidimetry.
  • Spearman's correlation analysis was employed to assess the relationship between MMP-3 levels and ophthalmic parameters.

Main Results:

  • Aqueous humor MMP-3 levels were significantly higher in the PSS group (25.86 ± 13.4 ng/ml) compared to the ARC control group (3.9 ± 2.7 ng/ml) (P < 0.001).
  • No significant difference in serum MMP-3 levels was observed between the PSS and ARC groups (P = 0.125).
  • Elevated aqueous humor MMP-3 showed a moderate correlation with intraocular pressure (IOP) and the difference in endothelial cell density (ECD) between the affected and fellow eyes in PSS patients.

Conclusions:

  • Matrix metalloproteinase-3 (MMP-3) is upregulated in the aqueous humor of patients with Posner-Schlossman syndrome (PSS).
  • These findings indicate that MMP-3 may contribute significantly to the pathological processes involved in PSS.
Keywords:
Posner-Schlossman syndromeaqueous humorimmunolatex turbidimetry methodmetalloproteinase-3ophthalmic examination

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