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Blood-brain barrier dysfunction in aging is mediated by brain endothelial senescence
João P Novo1,2,3, Lucy Gee4, Carolina A Caetano1,3
1CNC-UC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Aging Cell
|August 15, 2024
Abstract
None:
BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.
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