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Related Concept Videos

The Micturition Reflex01:26

The Micturition Reflex

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Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
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Updated: Jun 16, 2025

Transcorporal Artificial Urinary Sphincter Cuff Placement in a Case Requiring Revision for Urethral Atrophy
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Artificial urinary sphincter: recent developments and the way forward.

Christine Reus1, Stephanie Tran2, Pierre Mozer2

  • 1Section of Urology, Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden.

Current Opinion in Urology
|August 15, 2024
PubMed
Summary
This summary is machine-generated.

Novel artificial urinary sphincter (AUS) devices are emerging, with ongoing trials and new evidence enhancing treatment options for postprostatectomy urinary incontinence (PPUI). These advancements may soon challenge the current standard of care.

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Area of Science:

  • Urology
  • Medical Devices
  • Clinical Trials

Background:

  • The AMS 800 artificial urinary sphincter (AUS) has been the primary treatment for postprostatectomy urinary incontinence (PPUI) due to intrinsic sphincter deficiency (ISD).
  • A recent review was conducted to assess innovations and evidence surrounding AUS technology.

Purpose of the Study:

  • To review recent advancements in artificial urinary sphincter (AUS) technology for treating postprostatectomy urinary incontinence (PPUI).
  • To evaluate new AUS devices, clinical trial data, and current guidelines to inform future practices.

Main Methods:

  • A narrative review of literature published between June 2022 and June 2024 was performed.
  • Embase database was searched using 'artificial urinary sphincter' (AUS) MeSH terms.
  • Studies on innovative AUS, randomized controlled trials (RCTs), prospective studies, and systematic reviews were extracted and analyzed.

Main Results:

  • 145 papers were reviewed, with 24 selected, including studies on novel AUS in development, higher-level evidence (RCTs, systematic reviews), and retrospective analyses.
  • Key areas explored included pressure regulating balloons (PRB), revision strategies, and surgical approaches.
  • Recent guidelines from the Asia & Pacific region were summarized.

Conclusions:

  • Six novel artificial urinary sphincter (AUS) devices have emerged in the last two years.
  • Ongoing randomized controlled trials (RCTs) for female AUS and published outcomes from studies like SATURN are increasing the evidence base.
  • These developments position novel AUS devices to potentially become the new gold standard for treating PPUI.