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Related Experiment Video

Updated: Jun 16, 2025

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Evaluating fetal lung development at various gestational weeks using two-dimensional shear wave elastography.

Danyi Liu1, Qiuxia Jiang2, Ziwei Xu1

  • 1Department of Ultrasound, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Quantitative Imaging in Medicine and Surgery
|August 15, 2024
PubMed
Summary
This summary is machine-generated.

Two-dimensional shear-wave elastography (2D-SWE) noninvasively assesses fetal lung development. This technique shows promise in depicting lung maturity across gestational weeks, correlating with histological findings.

Keywords:
Fetahistologyliverlungtwo-dimensional shear-wave elastography (2D-SWE)

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Area of Science:

  • Obstetrics and Gynecology
  • Fetal Medicine
  • Medical Imaging

Background:

  • Noninvasive evaluation of fetal lung development is crucial for understanding prenatal growth.
  • Two-dimensional shear-wave elastography (2D-SWE) measures tissue stiffness, offering potential insights into lung maturity.

Purpose of the Study:

  • To explore the utility of 2D-SWE for assessing fetal lung development and maturity.
  • To correlate elastography measurements with gestational age and histological lung development stages.

Main Methods:

  • A prospective cohort study involving 300 normal pregnancies and 15 induced labor cases.
  • 2D-SWE was used to measure fetal lung and liver elasticity across gestational weeks.
  • Regression analyses and comparison with histological data from induced labor cases were performed.

Main Results:

  • Fetal lung and liver elasticity, and their ratio, varied significantly with gestational weeks (P<0.05).
  • Lung elasticity showed an initial increase followed by a decrease (R2=0.41), while liver elasticity steadily increased (R2=0.37).
  • A 71.4% concordance was found between 2D-SWE predicted lung development and histological stages.

Conclusions:

  • 2D-SWE is a viable noninvasive method for evaluating fetal lung maturation.
  • Elastography measurements correlate with gestational age and can predict lung development stages.